The Resource The role of the innate immune system in microbially induced intestinal inflammation and neoplasia, by Aaron C. Ericsson

The role of the innate immune system in microbially induced intestinal inflammation and neoplasia, by Aaron C. Ericsson

Label
The role of the innate immune system in microbially induced intestinal inflammation and neoplasia
Title
The role of the innate immune system in microbially induced intestinal inflammation and neoplasia
Statement of responsibility
by Aaron C. Ericsson
Creator
Contributor
Author
Thesis advisor
Subject
Genre
Language
eng
Summary
Inflammatory bowel disease (IBD) is one of the most common immune-mediated diseases in the United States costing the average patient tens of thousands of dollars annually, and greatly diminishing quality-of-life. While there is no universal cure for IBD, recently developed treatments targeting the immunological basis of disease have proven successful in managing clinical symptoms. However, these pharmaceutical therapies such as infliximab (Remicade[registered trademark]) carry several side effects and are not efficacious in all patients. Thus, more selective treatments are needed. One necessary step in the development of such agents is a more precise understanding of which cells in the gastrointestinal tract are primary contributors to the pathogenesis of IBD. We demonstrate that a rare subset of dendritic cells expressing CD8[alpha] is present in significantly different numbers in mouse strains considered susceptible or resistant to a microbially induced model of IBD. Additionally, we show that cells derived from the target organ of susceptible mice prior to and shortly after induction of the disease process are prone to production of greater levels of certain inflammatory mediators including IL-12/23p40, IP-10, RANTES, and TNF-[alpha]. Lastly, we describe the generation of a mouse strain susceptible to the disease model but selectively lacking the subset of dendritic cells expressing CD8[alpha], to be used in future studies. One of the most serious sequela to IBD is colitis-associated colorectal cancer (CAC). Diagnosis of colorectal cancer in general is reliant on tests that suffer from either poor sensitivity or specificity (such as fecal occult blood tests), or invasiveness (such as colonoscopy). Newer genetic tests have been developed for the identification of hereditary risk factors, however CAC follows a molecular pathway distinct from that of familial forms of colorectal cancer. Thus, the development of noninvasive screening assays for CAC with high sensitivity and specificity would increase compliance with screening recommendations and enhance detection and survival of patients with CAC. We report here the development of a novel screening technique capable of detecting the earliest stages of CAC in a microbially induced mouse model. Using fecal gene expression-based biomarkers, rRNA derived from colonocytes sloughed in the feces, we were able to accurately predict which mice would develop CAC several weeks later, as well as predict the severity of disease. While the optimal markers of disease identified in the present studies, IL-1[beta] and MIP-1[alpha], are likely specific to this model of CAC, the proof-of-concept portends a powerful new method of diagnostics for CAC in humans
Cataloging source
MUU
http://library.link/vocab/creatorDate
1971-
http://library.link/vocab/creatorName
Ericsson, Aaron C.
Degree
Ph.D.
Dissertation note
Dissertation
Dissertation year
2013.
Government publication
government publication of a state province territory dependency etc
Granting institution
University of Missouri--Columbia
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • theses
http://library.link/vocab/relatedWorkOrContributorName
Franklin, Craig L.
http://library.link/vocab/subjectName
  • Inflammatory bowel diseases
  • Inflammatory bowel diseases
  • Colon (Anatomy)
  • Gastroenterology
Label
The role of the innate immune system in microbially induced intestinal inflammation and neoplasia, by Aaron C. Ericsson
Instantiates
Publication
Copyright
Note
  • "A Dissertation presented to Faculty of the Graduate School University of Missouri In Partial Fulfillment of the Requirements for the Degree Doctor of Philosophy."
  • Dissertation supervisor: Dr. Craig Franklin
  • Vita
Bibliography note
Includes bibliographical references (pages 129-166)
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier.
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent.
Contents
Modeling of Inflammatory Bowel Disease and Colitis-associated Colorectal Cancer -- The Role of CD8[alpha]+ Dendritic Cells in Helicobacter hepaticus-induced Cecal Inflammation -- Noninvasive Detection of Colitis-associated Colorectal Cancer in Helicobacter bilis-infected Smad3-deficient Mice -- The Effect of Murine Norovirus on Two Chemically Induced Models of Inflammatory Bowel Disease -- Summary and Future Direction
Control code
891342327
Extent
1 online resource (xiv, pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia.
Media type code
  • c
Other physical details
illustrations (chiefly color)
Specific material designation
remote
System control number
(OCoLC)891342327
Label
The role of the innate immune system in microbially induced intestinal inflammation and neoplasia, by Aaron C. Ericsson
Publication
Copyright
Note
  • "A Dissertation presented to Faculty of the Graduate School University of Missouri In Partial Fulfillment of the Requirements for the Degree Doctor of Philosophy."
  • Dissertation supervisor: Dr. Craig Franklin
  • Vita
Bibliography note
Includes bibliographical references (pages 129-166)
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier.
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent.
Contents
Modeling of Inflammatory Bowel Disease and Colitis-associated Colorectal Cancer -- The Role of CD8[alpha]+ Dendritic Cells in Helicobacter hepaticus-induced Cecal Inflammation -- Noninvasive Detection of Colitis-associated Colorectal Cancer in Helicobacter bilis-infected Smad3-deficient Mice -- The Effect of Murine Norovirus on Two Chemically Induced Models of Inflammatory Bowel Disease -- Summary and Future Direction
Control code
891342327
Extent
1 online resource (xiv, pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia.
Media type code
  • c
Other physical details
illustrations (chiefly color)
Specific material designation
remote
System control number
(OCoLC)891342327

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