The Resource The role and mechanism of brain derived neurotrophic factor in autonomic and cardiovascular control in the nucleus tractus solitarii, by Catharine Grace Clark, (electronic resource)

The role and mechanism of brain derived neurotrophic factor in autonomic and cardiovascular control in the nucleus tractus solitarii, by Catharine Grace Clark, (electronic resource)

Label
The role and mechanism of brain derived neurotrophic factor in autonomic and cardiovascular control in the nucleus tractus solitarii
Title
The role and mechanism of brain derived neurotrophic factor in autonomic and cardiovascular control in the nucleus tractus solitarii
Statement of responsibility
by Catharine Grace Clark
Creator
Subject
Genre
Language
eng
Summary
The brainstem nucleus tractus solitarii (nTS) is the primary site at which cardiovascular afferent input is relayed to central autonomic pathways and plays a critical role in cardiovascular regulation. However, relatively little is known about mechanisms that underlie adaptation and plasticity in cardiovascular reflex circuits in the nTS. Brain derived neurotrophic factor (BDNF), a potent neuromodulator, is highly expressed within the nTS circuitry. Therefore the current studies were designed to determine if BDNF contributes to the central neural regulation of cardiovascular and autonomic function in the nTS. Findings presented in AIM 1 demonstrate that BDNF in nTS plays a novel tonic sympathoexcitatory role by modulating excitatory neurotransmission. In AIM 2 we extended our investigation to the cardiovascular disease model of the spontaneously hypertensive rat (SHR). Results from these studies demonstrate that acute removal of BDNF in the nTS of SHR reduces sympathetic overactivity and lowers blood pressure to normotensive control levels. In addition, nTS-BDNF signaling components are enhanced in the SHR. Collectively our data demonstrate a previously unrecognized role for BDNF in the central regulation of cardiovascular function. In addition, these findings raise the possibility that BDNF signaling in nTS may be a therapeutic target for regulating cardiovascular homeostasis in the setting of hypertension
Cataloging source
MMU
http://library.link/vocab/creatorDate
1977-
http://library.link/vocab/creatorName
Clark, Catharine Grace
Degree
Ph. D.
Dissertation year
2011.
Granting institution
University of Missouri-Columbia
Illustrations
illustrations
Index
no index present
LC call number
QP552.N36
Literary form
non fiction
Nature of contents
  • dictionaries
  • theses
  • bibliography
NLM call number
WL 104
http://library.link/vocab/subjectName
  • Neurotropin
  • Solitary nucleus
  • Neural transmission
  • Hypertension
  • Cardiovascular pharmacology
  • Autonomic nervous system
  • Brain-Derived Neurotrophic Factor
  • Solitary Nucleus
  • Autonomic Pathways
  • Hypertension
  • Cardiovascular Physiological Phenomena
  • Synaptic Transmission
Label
The role and mechanism of brain derived neurotrophic factor in autonomic and cardiovascular control in the nucleus tractus solitarii, by Catharine Grace Clark, (electronic resource)
Instantiates
Publication
Contributor
Thesis advisor
Note
  • The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file
  • Dissertation advisors: Dr. Eileen M. Hasser, Dr. David D. Kline
  • Vita
  • "May 2011"
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
817183564
Extent
1 online resource (x, 224 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Note
MU: Access is limited to the campuses of the University of Missouri.
Other physical details
illustrations (some color).
Specific material designation
remote
System control number
(OCoLC)817183564
Label
The role and mechanism of brain derived neurotrophic factor in autonomic and cardiovascular control in the nucleus tractus solitarii, by Catharine Grace Clark, (electronic resource)
Publication
Contributor
Thesis advisor
Note
  • The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file
  • Dissertation advisors: Dr. Eileen M. Hasser, Dr. David D. Kline
  • Vita
  • "May 2011"
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
817183564
Extent
1 online resource (x, 224 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Note
MU: Access is limited to the campuses of the University of Missouri.
Other physical details
illustrations (some color).
Specific material designation
remote
System control number
(OCoLC)817183564

Library Locations

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