The Resource Revealing the conformation and properties of human genome, protein molecules and protein domain co-occurrence network

Revealing the conformation and properties of human genome, protein molecules and protein domain co-occurrence network

Label
Revealing the conformation and properties of human genome, protein molecules and protein domain co-occurrence network
Title
Revealing the conformation and properties of human genome, protein molecules and protein domain co-occurrence network
Creator
Author
Subject
Language
eng
Summary
Deoxyribonucleic acid, or DNA, encodes genetic instructions for the functionalities of organisms. For human beings, 23 pairs of chromosomes, containing DNA strands, form a globule structure in the nucleus. This chromosomal conformation influences the subsequent biological processes including transcription and translation by positioning sequentially remote genes spatially close. Chapter 2 reveals human chromosomal conformation and studies gene-gene interactions and "transcription factor binding site" interactions based on chromosomal spatial proximity. Proteins are the biological units that conduct biological functions. The three-dimensional structure of a protein molecule determines its particular functions. Chapters 3 and 4 discuss research in predicting protein tertiary structures. Algorithms that can predict residue-specific qualities of predicted structures were constructed and benchmarked. A knowledge database of soybean transcription factors is presented in Chapter 5, which contains predicted protein tertiary structures. Chapter 6 shows a computer system predicting protein functions using profile-sequence alignment, profile-profile alignment, and protein domain co-occurrence network. A biological process is usually performed by multiple proteins. Biological network provides a global perspective of studying lives, which usually considers the entire set of the same type of biological molecules of the target organism. Chapter 7 introduces a novel biological network, protein Domain Co-occurrence Network (DCN), and demonstrates that DCN has great potentials in inferring species phylogenies and predicting protein functions
Cataloging source
MUU
http://library.link/vocab/creatorName
Wang, Zheng
Degree
Ph. D.
Dissertation note
Thesis
Dissertation year
2012.
Government publication
government publication of a state province territory dependency etc
Granting institution
University of Missouri--Columbia,
Index
no index present
Literary form
non fiction
Nature of contents
dictionaries
Label
Revealing the conformation and properties of human genome, protein molecules and protein domain co-occurrence network
Instantiates
Publication
Contributor
Thesis advisor
Note
Advisor: Jianlin Cheng
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier.
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent.
Control code
872566595
Extent
1 online resource (xxii, 214 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia.
Media type code
  • c
Specific material designation
remote
System control number
(OCoLC)872566595
Label
Revealing the conformation and properties of human genome, protein molecules and protein domain co-occurrence network
Publication
Contributor
Thesis advisor
Note
Advisor: Jianlin Cheng
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier.
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent.
Control code
872566595
Extent
1 online resource (xxii, 214 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia.
Media type code
  • c
Specific material designation
remote
System control number
(OCoLC)872566595

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