The Resource Regulations and functions of P2Y2 and P2X7 nucleotide receptors in the central nervous system, by Qiongman Kong, (electronic resource)

Regulations and functions of P2Y2 and P2X7 nucleotide receptors in the central nervous system, by Qiongman Kong, (electronic resource)

Label
Regulations and functions of P2Y2 and P2X7 nucleotide receptors in the central nervous system
Title
Regulations and functions of P2Y2 and P2X7 nucleotide receptors in the central nervous system
Statement of responsibility
by Qiongman Kong
Creator
Contributor
Thesis advisor
Subject
Genre
Language
eng
Summary
It is well known that ATP acts as a classic neurotransmitter in the central nervous system. It is stored in synaptic vesicles, released upon neuronal excitation, and activates both ion channel receptors (P2X) and G protein-coupled receptors (P2Y) on post-synaptic cells. In addition to its role as a neurotransmitter, ATP and other nucleotides are known to be released from injured or ischemic tissue and have been reported to affect inflammatory events in the brain and many other tissues, however, these inflammatory events as well as the subtype(s) of nucleotide receptor(s) influencing these events have not been well defined. This dissertation examines the expression patterns of P2X and P2Y nucleotide receptors in rat primary cultures of cortical neurons (rPCNs), in adult rodent brains, in cerebral ischemia and in collared rabbit carotid arteries. P2Y2R is up-regulated in response to cytokine stimulation in rPCNs in vitro and after collar transplantation around rabbit carotid arteries in vivo. Moreover, in vivo studies in the collared carotid artery model indicate the involvement of P2Y2Rs in the development of intimal hyperplasia. Based on these studies, particular emphasis was placed on delineating the role of the P2Y2 receptor subtype in neuronal inflammation and the P2X7 receptor subtype in neuronal apoptosis in the central nervous system. In the rat primary cultures of cortical neurons, activation of the P2Y2R and P2X7R caused á-secretase-dependent APP processing and caspase8/9/3-dependent apoptosis, respectively. These results suggest the important roles of P2 nucleotide receptors (P2Y2R and P2X7R) and their associated signaling pathways in regulating neuronal inflammation and apoptosis in brain disorders and neurodegeneration
Cataloging source
MUU
http://library.link/vocab/creatorDate
1979-
http://library.link/vocab/creatorName
Kong, Qiongman
Degree
Ph.D.
Dissertation year
2007.
Granting institution
University of Missouri-Columbia
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • theses
http://library.link/vocab/relatedWorkOrContributorName
Weisman, Gary A.
http://library.link/vocab/subjectName
  • Adenosine triphosphatase
  • Neurotransmitters
  • Central nervous system
  • Polymerase chain reaction
Target audience
specialized
Label
Regulations and functions of P2Y2 and P2X7 nucleotide receptors in the central nervous system, by Qiongman Kong, (electronic resource)
Instantiates
Publication
Note
  • The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file
  • Title from title screen of research.pdf file (viewed on March 19, 2009)
  • Vita
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
mixed
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
316337914
Dimensions
unknown
Form of item
electronic
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Specific material designation
remote
System control number
(OCoLC)316337914
System details
Mode of access: World Wide Web
Label
Regulations and functions of P2Y2 and P2X7 nucleotide receptors in the central nervous system, by Qiongman Kong, (electronic resource)
Publication
Note
  • The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file
  • Title from title screen of research.pdf file (viewed on March 19, 2009)
  • Vita
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
mixed
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
316337914
Dimensions
unknown
Form of item
electronic
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Specific material designation
remote
System control number
(OCoLC)316337914
System details
Mode of access: World Wide Web

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