The Resource Pulmonary fluid dynamics and aerosol drug delivery in the upper tracheobronchial airways under mechanical ventilation conditions, by Timothy Andrew Van Rhein

Pulmonary fluid dynamics and aerosol drug delivery in the upper tracheobronchial airways under mechanical ventilation conditions, by Timothy Andrew Van Rhein

Label
Pulmonary fluid dynamics and aerosol drug delivery in the upper tracheobronchial airways under mechanical ventilation conditions
Title
Pulmonary fluid dynamics and aerosol drug delivery in the upper tracheobronchial airways under mechanical ventilation conditions
Statement of responsibility
by Timothy Andrew Van Rhein
Creator
Author
Subject
Language
eng
Summary
"The effects of mechanical ventilation conditions on fluid flow and particle deposition were studied in a computer model of the human airways. The frequency with which aerosolized drugs are delivered to mechanically ventilated patients demonstrates the importance of understanding the effects that ventilation parameters have on particle deposition in the human airways. Past studies that modeled particle deposition in silico frequently used an idealized geometry with steady inlet conditions. With recent advancements in computational power and medical imaging capabilities, studies have begun to use more realistic geometries or unsteady inlet conditions that model normal breathing. This study focuses specifically on the effects of mechanical ventilation waveforms using a computer model of the airways from the endotracheal tube to generation 07, in the lungs of a patient undergoing mechanical ventilation treatment. Computational fluid dynamics (CFD), using the commercial software package ANSYS® CFX®, combined with realistic respiratory waveforms commonly used by commercial mechanical ventilators, large eddy simulation (LES) to model turbulence, and user defined particle force models were applied to solve for fluid flow and particle deposition parameters. The endotracheal tube (ETT) was found to be an important geometric feature, causing a fluid jet towards the right main bronchus, increased turbulence, and a recirculation zone in the right main bronchus. In addition to the enhanced deposition seen at the carinas of the airway bifurcations, enhanced deposition was also seen in the right main bronchus due to impaction and turbulent dispersion resulting from the fluid structures created by the ETT. The dependence of local particle deposition on respiratory waveforms implies that great care should be taken when selecting ventilation parameters"--Abstract, page iii
Member of
Cataloging source
UMR
http://library.link/vocab/creatorDate
1986-
http://library.link/vocab/creatorName
Van Rhein, Timothy Andrew
Degree
M.S.
Dissertation year
2012.
Granting institution
Missouri University of Science and Technology
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • theses
http://library.link/vocab/subjectName
  • Drug delivery systems
  • Aerosol therapy
  • Respiratory therapy
Label
Pulmonary fluid dynamics and aerosol drug delivery in the upper tracheobronchial airways under mechanical ventilation conditions, by Timothy Andrew Van Rhein
Instantiates
Publication
Note
Vita
Bibliography note
Includes bibliographical references (pages 139-148)
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
960196519
Extent
1 online resource (x, 149 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations (most colored).
Specific material designation
remote
System control number
(OCoLC)960196519
Label
Pulmonary fluid dynamics and aerosol drug delivery in the upper tracheobronchial airways under mechanical ventilation conditions, by Timothy Andrew Van Rhein
Publication
Note
Vita
Bibliography note
Includes bibliographical references (pages 139-148)
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
960196519
Extent
1 online resource (x, 149 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations (most colored).
Specific material designation
remote
System control number
(OCoLC)960196519

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