Coverart for item
The Resource Pharmacology in drug discovery : understanding drug response, Terry P. Kenakin

Pharmacology in drug discovery : understanding drug response, Terry P. Kenakin

Label
Pharmacology in drug discovery : understanding drug response
Title
Pharmacology in drug discovery
Title remainder
understanding drug response
Statement of responsibility
Terry P. Kenakin
Creator
Subject
Language
eng
Summary
Pharmacology in Drug Discovery: Understanding Drug Response is designed for all students, recent graduates, and new researchers in the pharmaceutical and biotechnology industries who need to interpret change in physiology induced by a chemical substance. Physiological systems customize chemical signal input to their own needs; therefore, the same drug can have different effects in different physiological systems. The field of pharmacology is unique in that it furnishes the tools to analyze these different behaviors and traces them to their root cause. This enables predictions of drug behavior to be made in all systems, an invaluable tool for drug discovery because almost all drugs are developed in test systems far removed from the therapeutic one. This valuable resource provides simple explanations of the ways in which biological systems use basic biochemical mechanisms to produce fine chemical control of physiology, allowing for more informed predictions of drug effects in all systems and forming the basis of the drug-discovery process. Chapters follow a logical progression on how to characterize the pharmacology of any given molecule and include important terminology, chapter summaries, references, and review questions to aid the reader in understanding and retention of the material. Bridges the gap between biochemistry and therapeutic medicine Chapters include key topics such as drug affinity and efficacy, enzymes as drug targets, in vivo pharmacology, safety pharmacology, and more Enables the reader to interpret drug dose-response data and make mechanistic inferences at the molecular level
Cataloging source
NLM
http://library.link/vocab/creatorName
Kenakin, Terrence P
Dewey number
615.1
Illustrations
  • illustrations
  • portraits
Index
index present
LC call number
RM301.35
LC item number
.K46 2012
Literary form
non fiction
Nature of contents
bibliography
NLM call number
  • 2011 L-173
  • QV 744
http://library.link/vocab/subjectName
  • Developmental pharmacology
  • Pharmacology
  • Drug development
  • Dose-Response Relationship, Drug
  • Drug Discovery
  • Drug Discovery
  • Pharmacological Phenomena
Label
Pharmacology in drug discovery : understanding drug response, Terry P. Kenakin
Instantiates
Publication
Bibliography note
Includes bibliographical references and index
Carrier category
volume
Carrier category code
  • nc
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Pharmacology : the chemical control of physiology -- Drug affinity and efficacy -- Predicting agonist effect -- Drug antagonism : orthosteric drug effects -- Allosteric drug effects -- Enzymes as drug targets -- Pharmacokinetics I : permeation and metabolism -- Pharmacokinetics II : distribution and multiple dosing -- In vivo pharmacology -- Safety pharmacology -- Appendix A. Answers to chapter questions -- Appendix B. Derivations and proofs
Control code
754167840
Dimensions
24 cm
Edition
1st ed.
Extent
xi, 247 pages
Isbn
9780123848567
Isbn Type
(pbk.)
Media category
unmediated
Media MARC source
rdamedia
Media type code
  • n
Other physical details
illustrations, portraits
System control number
(OCoLC)754167840
Label
Pharmacology in drug discovery : understanding drug response, Terry P. Kenakin
Publication
Bibliography note
Includes bibliographical references and index
Carrier category
volume
Carrier category code
  • nc
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Pharmacology : the chemical control of physiology -- Drug affinity and efficacy -- Predicting agonist effect -- Drug antagonism : orthosteric drug effects -- Allosteric drug effects -- Enzymes as drug targets -- Pharmacokinetics I : permeation and metabolism -- Pharmacokinetics II : distribution and multiple dosing -- In vivo pharmacology -- Safety pharmacology -- Appendix A. Answers to chapter questions -- Appendix B. Derivations and proofs
Control code
754167840
Dimensions
24 cm
Edition
1st ed.
Extent
xi, 247 pages
Isbn
9780123848567
Isbn Type
(pbk.)
Media category
unmediated
Media MARC source
rdamedia
Media type code
  • n
Other physical details
illustrations, portraits
System control number
(OCoLC)754167840

Library Locations

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