The Resource Part I: Synthesis of functionalized bile acids towards the construction of steroidal macrocycles. Part II: Evaluation and expansion of a modular card game for teaching organic chemistry, Christopher A. Knudtson
Part I: Synthesis of functionalized bile acids towards the construction of steroidal macrocycles. Part II: Evaluation and expansion of a modular card game for teaching organic chemistry, Christopher A. Knudtson
Resource Information
The item Part I: Synthesis of functionalized bile acids towards the construction of steroidal macrocycles. Part II: Evaluation and expansion of a modular card game for teaching organic chemistry, Christopher A. Knudtson represents a specific, individual, material embodiment of a distinct intellectual or artistic creation found in University of Missouri-Kansas City Libraries.This item is available to borrow from all library branches.
Resource Information
The item Part I: Synthesis of functionalized bile acids towards the construction of steroidal macrocycles. Part II: Evaluation and expansion of a modular card game for teaching organic chemistry, Christopher A. Knudtson represents a specific, individual, material embodiment of a distinct intellectual or artistic creation found in University of Missouri-Kansas City Libraries.
This item is available to borrow from all library branches.
- Summary
- In Part I, the synthesis of chenodeoxychoic acid (CDCA) derivatives towards the construction of unique chemical architectures are reported. Building on previously described methods, CDCA based macrocycles with inner cavities have been synthesized and characterized. Attempts toward oxa-Michael coupling of CDCA monomers to form sulfonate ester linked dimmers is described. CDCA was also functionalized with terminal alkynes (pentynyl, hexynyl, and heptynyl) and aryl iodide and cyclized to from the respective macrocycles. These have been coupled together via oxygen-free Sonogashira reaction conditions to form large barrel-like steroidal architectures. These structures were investigated by 1H NMR, 13C NMR spectroscopy, and HR-MS, and MALDI-TOF spectroscopy. In part II a game to teach organic chemistry, ChemKarta was evaluated as a teaching tool. Analysis of an undergraduate class's impressions of the game showed that Chemkarta was an easy to learn and enjoyable game, but the amount of information in the game could be overwhelming for some students. Furthermore, the modular nature of the game was demonstrated by developing new cards to fit into the examined card set, as well as additional card sets to teach different subjects using the same game rules
- Language
- eng
- Extent
- 1 online resource (316 pages)
- Note
-
- "A dissertation in Chemistry and Pharmaceutical Sciences."
- Advisor: Theodore White
- Vita
- Contents
-
- Introduction
- Literature review
- Oxa-Michael strategies toward CDCA dimers
- Synthesis of bile acids derivatives towards macrocycle construction via Sonogashara coupling
- Evaluation and expansion of Chemkarta
- Conclusion
- Appendix A. Functional groups
- Appendix B. Functional Groups Victory and Technique Cards --Appendix C. Structure and bonding
- Appendix D. Name reactions
- Label
- Part I: Synthesis of functionalized bile acids towards the construction of steroidal macrocycles. Part II: Evaluation and expansion of a modular card game for teaching organic chemistry
- Title
- Part I: Synthesis of functionalized bile acids towards the construction of steroidal macrocycles. Part II: Evaluation and expansion of a modular card game for teaching organic chemistry
- Statement of responsibility
- Christopher A. Knudtson
- Title variation
-
- Synthesis of functionalized bile acids towards the construction of steroidal macrocycles
- Evaluation and expansion of a modular card game for teaching organic chemistry
- Language
- eng
- Summary
- In Part I, the synthesis of chenodeoxychoic acid (CDCA) derivatives towards the construction of unique chemical architectures are reported. Building on previously described methods, CDCA based macrocycles with inner cavities have been synthesized and characterized. Attempts toward oxa-Michael coupling of CDCA monomers to form sulfonate ester linked dimmers is described. CDCA was also functionalized with terminal alkynes (pentynyl, hexynyl, and heptynyl) and aryl iodide and cyclized to from the respective macrocycles. These have been coupled together via oxygen-free Sonogashira reaction conditions to form large barrel-like steroidal architectures. These structures were investigated by 1H NMR, 13C NMR spectroscopy, and HR-MS, and MALDI-TOF spectroscopy. In part II a game to teach organic chemistry, ChemKarta was evaluated as a teaching tool. Analysis of an undergraduate class's impressions of the game showed that Chemkarta was an easy to learn and enjoyable game, but the amount of information in the game could be overwhelming for some students. Furthermore, the modular nature of the game was demonstrated by developing new cards to fit into the examined card set, as well as additional card sets to teach different subjects using the same game rules
- Cataloging source
- UMK
- http://library.link/vocab/creatorDate
- 1982-
- http://library.link/vocab/creatorName
- Knudtson, Christopher A.
- Degree
- Ph.D.
- Dissertation note
- (Department of Chemistry, School of Pharmacy).
- Dissertation year
- 2019.
- Granting institution
- University of Missouri-Kansas City,
- Illustrations
- illustrations
- Index
- no index present
- Literary form
- non fiction
- Nature of contents
-
- dictionaries
- bibliography
- theses
- http://library.link/vocab/relatedWorkOrContributorName
- White, Theodore
- http://library.link/vocab/subjectName
-
- Bile acids
- Steroids
- Chemistry, Organic
- Label
- Part I: Synthesis of functionalized bile acids towards the construction of steroidal macrocycles. Part II: Evaluation and expansion of a modular card game for teaching organic chemistry, Christopher A. Knudtson
- Note
-
- "A dissertation in Chemistry and Pharmaceutical Sciences."
- Advisor: Theodore White
- Vita
- Antecedent source
- not applicable
- Bibliography note
- Includes bibliographical references (pages 252-253)
- Carrier category
- online resource
- Carrier category code
-
- cr
- Carrier MARC source
- rdacarrier
- Color
- black and white
- Content category
- text
- Content type code
-
- txt
- Content type MARC source
- rdacontent
- Contents
- Introduction -- Literature review -- Oxa-Michael strategies toward CDCA dimers -- Synthesis of bile acids derivatives towards macrocycle construction via Sonogashara coupling -- Evaluation and expansion of Chemkarta -- Conclusion -- Appendix A. Functional groups -- Appendix B. Functional Groups Victory and Technique Cards --Appendix C. Structure and bonding -- Appendix D. Name reactions
- Control code
- 1135980750
- Dimensions
- unknown
- Extent
- 1 online resource (316 pages)
- File format
- one file format
- Form of item
- online
- Level of compression
- mixed
- Media category
- computer
- Media MARC source
- rdamedia
- Media type code
-
- c
- Other physical details
- illustrations.
- Quality assurance targets
- not applicable
- Specific material designation
- remote
- System control number
- (OCoLC)1135980750
- System details
-
- The full text of the dissertation is available as an Adobe Acrobat .pdf file; Adobe Acrobat Reader required to view the file
- Mode of access: World Wide Web
- Label
- Part I: Synthesis of functionalized bile acids towards the construction of steroidal macrocycles. Part II: Evaluation and expansion of a modular card game for teaching organic chemistry, Christopher A. Knudtson
- Note
-
- "A dissertation in Chemistry and Pharmaceutical Sciences."
- Advisor: Theodore White
- Vita
- Antecedent source
- not applicable
- Bibliography note
- Includes bibliographical references (pages 252-253)
- Carrier category
- online resource
- Carrier category code
-
- cr
- Carrier MARC source
- rdacarrier
- Color
- black and white
- Content category
- text
- Content type code
-
- txt
- Content type MARC source
- rdacontent
- Contents
- Introduction -- Literature review -- Oxa-Michael strategies toward CDCA dimers -- Synthesis of bile acids derivatives towards macrocycle construction via Sonogashara coupling -- Evaluation and expansion of Chemkarta -- Conclusion -- Appendix A. Functional groups -- Appendix B. Functional Groups Victory and Technique Cards --Appendix C. Structure and bonding -- Appendix D. Name reactions
- Control code
- 1135980750
- Dimensions
- unknown
- Extent
- 1 online resource (316 pages)
- File format
- one file format
- Form of item
- online
- Level of compression
- mixed
- Media category
- computer
- Media MARC source
- rdamedia
- Media type code
-
- c
- Other physical details
- illustrations.
- Quality assurance targets
- not applicable
- Specific material designation
- remote
- System control number
- (OCoLC)1135980750
- System details
-
- The full text of the dissertation is available as an Adobe Acrobat .pdf file; Adobe Acrobat Reader required to view the file
- Mode of access: World Wide Web
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<div class="citation" vocab="http://schema.org/"><i class="fa fa-external-link-square fa-fw"></i> Data from <span resource="http://link.library.umkc.edu/portal/Part-I-Synthesis-of-functionalized-bile-acids/c0fFoSQcl6w/" typeof="Book http://bibfra.me/vocab/lite/Item"><span property="name http://bibfra.me/vocab/lite/label"><a href="http://link.library.umkc.edu/portal/Part-I-Synthesis-of-functionalized-bile-acids/c0fFoSQcl6w/">Part I: Synthesis of functionalized bile acids towards the construction of steroidal macrocycles. Part II: Evaluation and expansion of a modular card game for teaching organic chemistry, Christopher A. Knudtson</a></span> - <span property="potentialAction" typeOf="OrganizeAction"><span property="agent" typeof="LibrarySystem http://library.link/vocab/LibrarySystem" resource="http://link.library.umkc.edu/"><span property="name http://bibfra.me/vocab/lite/label"><a property="url" href="http://link.library.umkc.edu/">University of Missouri-Kansas City Libraries</a></span></span></span></span></div>
