The Resource Genome scale meta analysis of microarrays for biological inferences, by Gyan Prakash Srivastava, (electronic resource)

Genome scale meta analysis of microarrays for biological inferences, by Gyan Prakash Srivastava, (electronic resource)

Label
Genome scale meta analysis of microarrays for biological inferences
Title
Genome scale meta analysis of microarrays for biological inferences
Statement of responsibility
by Gyan Prakash Srivastava
Creator
Contributor
Thesis advisor
Subject
Genre
Language
eng
Summary
In this present era of high-throughput technologies, meta-analysis is being widely used to integrate multiple similar high throughput studies. Here we propose a novel framework for applying meta-analysis techniques on expression data for gene function characterizations and biological networks construction like the gene regulatory network. In particular, we developed a prototype for gene function annotation using multiple microarray datasets and tested the performance of our model using yeast and human microarray datasets. Our results show significant improvement in functional annotation in general. We further applied the same metaanalysis method on the Arabidopsis plant in a collaborative project with Monsanto Company to construct regulatory network for Arabidopsis. Our method shows significant improvement than any other existing methods for inferring gene regulatory network. Beside meta-analysis, I have invested a great deal of efforts in developing PRIMEGENS, an open source software, which could be used for large-scale primers and probe design for PCR, DNA synthesis, qRT-PCR (gene expression), and targeted next-generation sequencing (454, Solexa, Agilent sure-select technology etc.) for normal or bisulfite-treated genome. We recently extended its functionality including microarray probe design to cover genome-wide CpG islands in human, Taqman probes and discriminating transcripts from its multiple homologs or splice variants based on gene-specific unique fragment in soybean genome
Cataloging source
MUU
http://library.link/vocab/creatorDate
1979-
http://library.link/vocab/creatorName
Srivastava, Gyan Prakash
Degree
Ph. D.
Dissertation year
2009.
Granting institution
University of Missouri--Columbia
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • theses
http://library.link/vocab/relatedWorkOrContributorDate
1965-
http://library.link/vocab/relatedWorkOrContributorName
Xu, Dong
http://library.link/vocab/subjectName
  • Genomics
  • Gene expression
  • DNA microarrays
  • Arabidopsis
Target audience
specialized
Label
Genome scale meta analysis of microarrays for biological inferences, by Gyan Prakash Srivastava, (electronic resource)
Instantiates
Publication
Note
  • Title from PDF of title page (University of Missouri--Columbia, viewed on April 5, 2010)
  • The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file
  • Dissertation advisor: Dr. Dong Xu
  • Vita
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
605910441
Extent
1 online resource (viii, 123 pages)
Form of item
electronic
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations (some color).
Specific material designation
remote
System control number
(OCoLC)605910441
Label
Genome scale meta analysis of microarrays for biological inferences, by Gyan Prakash Srivastava, (electronic resource)
Publication
Note
  • Title from PDF of title page (University of Missouri--Columbia, viewed on April 5, 2010)
  • The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file
  • Dissertation advisor: Dr. Dong Xu
  • Vita
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
605910441
Extent
1 online resource (viii, 123 pages)
Form of item
electronic
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations (some color).
Specific material designation
remote
System control number
(OCoLC)605910441

Library Locations

  • Health Sciences LibraryBorrow it
    2411 Holmes St, Kansas City, Kansas City, MO, 64108, US
    39.083418 -94.575323
  • LaBudde Special CollectionsBorrow it
    800 E 51st St, Kansas City, MO, 64110, US
    39.034642 -94.576835
  • Leon E. Bloch Law LibraryBorrow it
    500 E. 52nd Street, Kansas City, MO, 64110, US
    39.032488 -94.581967
  • Marr Sound ArchivesBorrow it
    800 E 51st St, Kansas City, MO, 64110, US
    39.034642 -94.576835
  • Miller Nichols LibraryBorrow it
    800 E 51st St, Kansas City, MO, 64110, US
    39.035061 -94.576518
  • UMKCBorrow it
    800 E 51st St, Kansas City, MO, 64110, US
    39.035061 -94.576518
  • UMKCBorrow it
    800 E 51st St, Kansas City, MO, 64110, US
Processing Feedback ...