The Resource Functional and structural modifications associated with hypertension, obesity and diabetes in the resistance vasculature, by Jorge A. Castorena-Gonzalez

Functional and structural modifications associated with hypertension, obesity and diabetes in the resistance vasculature, by Jorge A. Castorena-Gonzalez

Label
Functional and structural modifications associated with hypertension, obesity and diabetes in the resistance vasculature
Title
Functional and structural modifications associated with hypertension, obesity and diabetes in the resistance vasculature
Statement of responsibility
by Jorge A. Castorena-Gonzalez
Creator
Contributor
Author
Thesis advisor
Subject
Genre
Language
eng
Summary
Cardiovascular diseases are considered the leading cause of death nowadays. Hypertension, obesity and type-2 diabetes are deemed major risk factors for the development of cardiovascular diseases. In essential hypertension, one of the most important structural changes is the inward remodeling of the resistance arteries. I found that the mechanical properties of inwardly remodeled cremasteric-arterioles from rats are affected. Furthermore, it is the F-actin components of the cytoskeleton the ones that are strongly modified. In old spontaneously hypertensive rats, my results showed that, resistance arteries undergo hypertrophic inward remodeling; and, adrenergicvasoconstriction and vasodilation pathways are impaired. In diet-induced-obesity, micemesenteric arterioles were observed to undergo remodeling of the extracellular matrix components. Obesity and type-2 diabetes have been associated with insulin resistance, endothelial dysfunction and arterial stiffening. Jejunal-submucosal arterioles from diabetic obese patients had a reduced vasorelaxation to insulin in comparison to obese non-diabetics, while acetylcholine-vasodilation was similar in both groups. Reduced amounts of the subunit-alpha of the insulin receptor and MMP-9 were found in diabetics as well. This suggests that, in type-2 diabetes, the presence of a blunted insulinvasodilation response is a form of endothelial dysfunction that is not correlated with the body-to-mass index, but whose mechanism may be related with the activity of MMPs
Cataloging source
MUU
http://library.link/vocab/creatorName
Castorena-González, Jorge A
Degree
Ph.D.
Dissertation note
Dissertation
Dissertation year
2014.
Government publication
government publication of a state province territory dependency etc
Granting institution
University of Missouri--Columbia
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • theses
http://library.link/vocab/relatedWorkOrContributorDate
1965-
http://library.link/vocab/relatedWorkOrContributorName
  • Martinez Lemus, Luis Arturo
  • Polo-Parada, Luis
Label
Functional and structural modifications associated with hypertension, obesity and diabetes in the resistance vasculature, by Jorge A. Castorena-Gonzalez
Instantiates
Publication
Note
  • "December 2014."
  • "A Dissertation Presented to the Faculty of the Graduate School at the University of Missouri--Columbia In Partial Fulfillment of the Requirements for the Degree Doctor of Philosophy."
  • Dissertation Supervisors: Dr. Luis A. Martinez-Lemus and Luis Polo-Parada
  • Includes vita
Bibliography note
Includes bibliographical references (pages 124-146)
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier.
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent.
Control code
917605443
Extent
1 online resource (3 files)
Form of item
online
Media category
computer
Media MARC source
rdamedia.
Media type code
  • c
Other physical details
illustrations (some color)
Specific material designation
remote
System control number
(OCoLC)917605443
Label
Functional and structural modifications associated with hypertension, obesity and diabetes in the resistance vasculature, by Jorge A. Castorena-Gonzalez
Publication
Note
  • "December 2014."
  • "A Dissertation Presented to the Faculty of the Graduate School at the University of Missouri--Columbia In Partial Fulfillment of the Requirements for the Degree Doctor of Philosophy."
  • Dissertation Supervisors: Dr. Luis A. Martinez-Lemus and Luis Polo-Parada
  • Includes vita
Bibliography note
Includes bibliographical references (pages 124-146)
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier.
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent.
Control code
917605443
Extent
1 online resource (3 files)
Form of item
online
Media category
computer
Media MARC source
rdamedia.
Media type code
  • c
Other physical details
illustrations (some color)
Specific material designation
remote
System control number
(OCoLC)917605443

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