The Resource Development of novel breast cancer-targeted spect imaging peptides by phage display, by Benjamin M. Larimer

Development of novel breast cancer-targeted spect imaging peptides by phage display, by Benjamin M. Larimer

Label
Development of novel breast cancer-targeted spect imaging peptides by phage display
Title
Development of novel breast cancer-targeted spect imaging peptides by phage display
Statement of responsibility
by Benjamin M. Larimer
Creator
Contributor
Author
Thesis advisor
Subject
Genre
Language
eng
Summary
Malignancy of the breast is the leading cause of cancer among women and the second leading cause of cancer-related death. Despite implementation of mammograms and breast exams, there still exists a need to detect highly aggressive cancer at its earliest stage. Development of targeted molecules, such as peptides, by phage display allows for specific imaging of a targeted antigen. The hypothesis of this dissertation was that phage display could be used select novel peptides for breast cancer imaging. In vivo phage display selection is a strategy that allows for selection of peptides based on their function in the environment in which they will be used. The work here demonstrated that in vivo phage display successfully was able to select a peptide with improved pharmacokinetics and tumor targeting in comparison to a previous generation. Additionally, the selection yielded a peptide that mimicked a putative tumor vasculature. associated protein termed EGFL6. EGFL6 was determined to be expressed in breast cancer and may serve as the basis for future investigations. Finally, a peptide was discovered that bound to and imaged BT-474 human breast cancer tumors in mice. This cell line is of importance because it represents resistance susceptible breast cancer, a major cause of death among women. These results demonstrate the utility of phage display and highlight the novel targeting agents that can be obtained by the technology
Cataloging source
MUU
http://library.link/vocab/creatorDate
1986-
http://library.link/vocab/creatorName
Larimer, Benjamin M.
Degree
Ph.D.
Dissertation note
Dissertation
Dissertation year
2014.
Government publication
government publication of a state province territory dependency etc
Granting institution
University of Missouri--Columbia
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • theses
http://library.link/vocab/relatedWorkOrContributorName
Deutscher, Susan L.
Label
Development of novel breast cancer-targeted spect imaging peptides by phage display, by Benjamin M. Larimer
Instantiates
Publication
Note
  • "May 2014."
  • "A Dissertation Presented to the Faculty of the Graduate School University of Missouri--Columbia In Partial Fulfillment of the Requirements for the Degree Doctor of Philosophy."
  • Dissertation Supervisor: Dr. Susan L. Deutscher
  • Includes vita
Bibliography note
Includes bibliographical references (pages 137-151)
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier.
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent.
Control code
905911692
Extent
1 online resource (3 files)
Form of item
online
Media category
computer
Media MARC source
rdamedia.
Media type code
  • c
Other physical details
illustrations (some color)
Specific material designation
remote
System control number
(OCoLC)905911692
Label
Development of novel breast cancer-targeted spect imaging peptides by phage display, by Benjamin M. Larimer
Publication
Note
  • "May 2014."
  • "A Dissertation Presented to the Faculty of the Graduate School University of Missouri--Columbia In Partial Fulfillment of the Requirements for the Degree Doctor of Philosophy."
  • Dissertation Supervisor: Dr. Susan L. Deutscher
  • Includes vita
Bibliography note
Includes bibliographical references (pages 137-151)
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier.
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent.
Control code
905911692
Extent
1 online resource (3 files)
Form of item
online
Media category
computer
Media MARC source
rdamedia.
Media type code
  • c
Other physical details
illustrations (some color)
Specific material designation
remote
System control number
(OCoLC)905911692

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