The Resource Acute & subchronic NMDA receptor blockade alters nicotine-evoked dopamine release, by Kelli Renee Rodvelt, (electronic resource)
Acute & subchronic NMDA receptor blockade alters nicotine-evoked dopamine release, by Kelli Renee Rodvelt, (electronic resource)
Resource Information
The item Acute & subchronic NMDA receptor blockade alters nicotine-evoked dopamine release, by Kelli Renee Rodvelt, (electronic resource) represents a specific, individual, material embodiment of a distinct intellectual or artistic creation found in University of Missouri-Kansas City Libraries.This item is available to borrow from all library branches.
Resource Information
The item Acute & subchronic NMDA receptor blockade alters nicotine-evoked dopamine release, by Kelli Renee Rodvelt, (electronic resource) represents a specific, individual, material embodiment of a distinct intellectual or artistic creation found in University of Missouri-Kansas City Libraries.
This item is available to borrow from all library branches.
- Summary
- Blockade of ionotropic glutamate receptors can induce changes in central dopamine and glutamate circuits, which model the symptoms of schizophrenia. Nicotine evokes dopamine release through activation of nicotinic acetylcholine receptors, and human research indicates that nicotine improves negative and cognitive symptoms of schizophrenia. The objective was to determine the effect of the glutamate receptor antagonist, ketamine, on the function of nicotinic receptors that mediate dopamine release. Ketamine did not have intrinsic activity to evoke dopamine release from rat striatal or prefrontal cortical slices. Acute NMDA receptor blockade augmented the effect of nicotine to evoke dopamine release. To model progression of schizophrenia, rats received injections of either a high or low dose of ketamine or vehicle for 30 days and then nicotine-evoked dopamine release was measured. Subchronic NMDA receptor blockade altered the effect of nicotine to evoke dopamine release. Overall, these data indicate that nicotinic receptor function is altered in this model of schizophrenia, and support a role for nicotinic receptors in schizophrenia treatment
- Language
- eng
- Note
-
- The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file
- Title from title screen of research.pdf file (viewed on April 10, 2009)
- Label
- Acute & subchronic NMDA receptor blockade alters nicotine-evoked dopamine release
- Title
- Acute & subchronic NMDA receptor blockade alters nicotine-evoked dopamine release
- Statement of responsibility
- by Kelli Renee Rodvelt
- Title variation
- Acute and subchronic NMDA receptor blockade alters nicotine-evoked dopamine release
- Language
- eng
- Summary
- Blockade of ionotropic glutamate receptors can induce changes in central dopamine and glutamate circuits, which model the symptoms of schizophrenia. Nicotine evokes dopamine release through activation of nicotinic acetylcholine receptors, and human research indicates that nicotine improves negative and cognitive symptoms of schizophrenia. The objective was to determine the effect of the glutamate receptor antagonist, ketamine, on the function of nicotinic receptors that mediate dopamine release. Ketamine did not have intrinsic activity to evoke dopamine release from rat striatal or prefrontal cortical slices. Acute NMDA receptor blockade augmented the effect of nicotine to evoke dopamine release. To model progression of schizophrenia, rats received injections of either a high or low dose of ketamine or vehicle for 30 days and then nicotine-evoked dopamine release was measured. Subchronic NMDA receptor blockade altered the effect of nicotine to evoke dopamine release. Overall, these data indicate that nicotinic receptor function is altered in this model of schizophrenia, and support a role for nicotinic receptors in schizophrenia treatment
- Cataloging source
- MUU
- http://library.link/vocab/creatorDate
- 1981-
- http://library.link/vocab/creatorName
- Rodvelt, Kelli Renee
- Degree
- M.A.
- Dissertation year
- 2007.
- Granting institution
- University of Missouri-Columbia
- Illustrations
- illustrations
- Index
- no index present
- Literary form
- non fiction
- Nature of contents
-
- dictionaries
- bibliography
- theses
- http://library.link/vocab/relatedWorkOrContributorName
- Miller, Dennis K.
- http://library.link/vocab/subjectName
-
- Dopamine
- Schizophrenia
- Nicotinic receptors
- Target audience
- specialized
- Label
- Acute & subchronic NMDA receptor blockade alters nicotine-evoked dopamine release, by Kelli Renee Rodvelt, (electronic resource)
- Note
-
- The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file
- Title from title screen of research.pdf file (viewed on April 10, 2009)
- Bibliography note
- Includes bibliographical references
- Carrier category
- online resource
- Carrier category code
-
- cr
- Carrier MARC source
- rdacarrier
- Color
- mixed
- Content category
- text
- Content type code
-
- txt
- Content type MARC source
- rdacontent
- Control code
- 318215925
- Dimensions
- unknown
- Form of item
- electronic
- Media category
- computer
- Media MARC source
- rdamedia
- Media type code
-
- c
- Specific material designation
- remote
- System control number
- (OCoLC)318215925
- System details
- Mode of access: World Wide Web
- Label
- Acute & subchronic NMDA receptor blockade alters nicotine-evoked dopamine release, by Kelli Renee Rodvelt, (electronic resource)
- Note
-
- The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file
- Title from title screen of research.pdf file (viewed on April 10, 2009)
- Bibliography note
- Includes bibliographical references
- Carrier category
- online resource
- Carrier category code
-
- cr
- Carrier MARC source
- rdacarrier
- Color
- mixed
- Content category
- text
- Content type code
-
- txt
- Content type MARC source
- rdacontent
- Control code
- 318215925
- Dimensions
- unknown
- Form of item
- electronic
- Media category
- computer
- Media MARC source
- rdamedia
- Media type code
-
- c
- Specific material designation
- remote
- System control number
- (OCoLC)318215925
- System details
- Mode of access: World Wide Web
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<div class="citation" vocab="http://schema.org/"><i class="fa fa-external-link-square fa-fw"></i> Data from <span resource="http://link.library.umkc.edu/portal/Acute--subchronic-NMDA-receptor-blockade-alters/ZoAC43Y2AyE/" typeof="Book http://bibfra.me/vocab/lite/Item"><span property="name http://bibfra.me/vocab/lite/label"><a href="http://link.library.umkc.edu/portal/Acute--subchronic-NMDA-receptor-blockade-alters/ZoAC43Y2AyE/">Acute & subchronic NMDA receptor blockade alters nicotine-evoked dopamine release, by Kelli Renee Rodvelt, (electronic resource)</a></span> - <span property="potentialAction" typeOf="OrganizeAction"><span property="agent" typeof="LibrarySystem http://library.link/vocab/LibrarySystem" resource="http://link.library.umkc.edu/"><span property="name http://bibfra.me/vocab/lite/label"><a property="url" href="http://link.library.umkc.edu/">University of Missouri-Kansas City Libraries</a></span></span></span></span></div>
