The Resource Acute & subchronic NMDA receptor blockade alters nicotine-evoked dopamine release, by Kelli Renee Rodvelt, (electronic resource)

Acute & subchronic NMDA receptor blockade alters nicotine-evoked dopamine release, by Kelli Renee Rodvelt, (electronic resource)

Label
Acute & subchronic NMDA receptor blockade alters nicotine-evoked dopamine release
Title
Acute & subchronic NMDA receptor blockade alters nicotine-evoked dopamine release
Statement of responsibility
by Kelli Renee Rodvelt
Title variation
Acute and subchronic NMDA receptor blockade alters nicotine-evoked dopamine release
Creator
Contributor
Thesis advisor
Subject
Genre
Language
eng
Summary
Blockade of ionotropic glutamate receptors can induce changes in central dopamine and glutamate circuits, which model the symptoms of schizophrenia. Nicotine evokes dopamine release through activation of nicotinic acetylcholine receptors, and human research indicates that nicotine improves negative and cognitive symptoms of schizophrenia. The objective was to determine the effect of the glutamate receptor antagonist, ketamine, on the function of nicotinic receptors that mediate dopamine release. Ketamine did not have intrinsic activity to evoke dopamine release from rat striatal or prefrontal cortical slices. Acute NMDA receptor blockade augmented the effect of nicotine to evoke dopamine release. To model progression of schizophrenia, rats received injections of either a high or low dose of ketamine or vehicle for 30 days and then nicotine-evoked dopamine release was measured. Subchronic NMDA receptor blockade altered the effect of nicotine to evoke dopamine release. Overall, these data indicate that nicotinic receptor function is altered in this model of schizophrenia, and support a role for nicotinic receptors in schizophrenia treatment
Cataloging source
MUU
http://library.link/vocab/creatorDate
1981-
http://library.link/vocab/creatorName
Rodvelt, Kelli Renee
Degree
M.A.
Dissertation year
2007.
Granting institution
University of Missouri-Columbia
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • theses
http://library.link/vocab/relatedWorkOrContributorName
Miller, Dennis K.
http://library.link/vocab/subjectName
  • Dopamine
  • Schizophrenia
  • Nicotinic receptors
Target audience
specialized
Label
Acute & subchronic NMDA receptor blockade alters nicotine-evoked dopamine release, by Kelli Renee Rodvelt, (electronic resource)
Instantiates
Publication
Note
  • The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file
  • Title from title screen of research.pdf file (viewed on April 10, 2009)
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
mixed
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
318215925
Dimensions
unknown
Form of item
electronic
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Specific material designation
remote
System control number
(OCoLC)318215925
System details
Mode of access: World Wide Web
Label
Acute & subchronic NMDA receptor blockade alters nicotine-evoked dopamine release, by Kelli Renee Rodvelt, (electronic resource)
Publication
Note
  • The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file
  • Title from title screen of research.pdf file (viewed on April 10, 2009)
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
mixed
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
318215925
Dimensions
unknown
Form of item
electronic
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Specific material designation
remote
System control number
(OCoLC)318215925
System details
Mode of access: World Wide Web

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